RGDS- and SIKVAVS-modified superporous poly(2-hydroxyethyl methacrylate) scaffolds for tissue engineering applications
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F16%3A00465604" target="_blank" >RIV/68378041:_____/16:00465604 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/16:00465604
Result on the web
<a href="http://dx.doi.org/10.1002/mabi.201600159" target="_blank" >http://dx.doi.org/10.1002/mabi.201600159</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.201600159" target="_blank" >10.1002/mabi.201600159</a>
Alternative languages
Result language
angličtina
Original language name
RGDS- and SIKVAVS-modified superporous poly(2-hydroxyethyl methacrylate) scaffolds for tissue engineering applications
Original language description
Three-dimensional hydrogel supports for mesenchymal and neural stem cells (NSCs) are promising materials for tissue engineering applications such as spinal cord repair. This study involves the preparation and characterization of superporous scaffolds based on a copolymer of 2-hydroxyethyl and 2-aminoethyl methacrylate (HEMA and AEMA) crosslinked with ethylene dimethacrylate. Ammonium oxalate is chosen as a suitable porogen because it consists of needle-like crystals, allowing their parallel arrangement in the polymerization mold. The amino group of AEMA is used to immobilize RGDS and SIKVAVS peptide sequences with an N-γ-maleimidobutyryloxy succinimide ester linker. The amount of the peptide on the scaffold is determined using 125I radiolabeled SIKVAVS. Both RGDS- and SIKVAVS-modified poly(2-hydroxyethyl methacrylate) scaffolds serve as supports for culturing human mesenchymal stem cells (MSCs) and human fetal NSCs. The RGDS sequence is found to be better for MSC and NSC proliferation and growth than SIKVAVS.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Macromolecular Bioscience
ISSN
1616-5187
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
1621-1631
UT code for WoS article
000389084800008
EID of the result in the Scopus database
2-s2.0-84989221413