Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00469319" target="_blank" >RIV/68378041:_____/17:00469319 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10327401 RIV/00216208:11140/17:10327401 RIV/00064190:_____/17:N0000089

Result on the web

<a href="http://dx.doi.org/10.1093/carcin/bgw114" target="_blank" >http://dx.doi.org/10.1093/carcin/bgw114</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/carcin/bgw114" target="_blank" >10.1093/carcin/bgw114</a>

Result language

angličtina

Original language name

Polymorphisms in microRNA binding sites of mucin genes as predictors of clinical outcome in colorectal cancer patients

Original language description

Polymorphisms in microRNA (miRNA) binding sites may affect miRNA/target gene interaction, resulting in differential mRNA/protein expression and susceptibility to common diseases. Mucins have been identified as markers of adverse prognosis. We hypothesized that genetic variations in miRNA binding sites located in mucin genes may modulate signaling response and the maintenance of genomic stability ultimately affecting cancer susceptibility, efficacy of chemotherapy and survival. In this study, we analyzed the association of single nucleotide polymorphisms in predicted miRNA target sites (miRSNPs) of mucin genes with colorectal cancer (CRC) risk and clinical outcome. Thirteen miRSNPs in 9 genes were assessed in 1111 cases and 1469 controls. No strongly significant associations were observed in the case-control study. Patients carrying the CC genotype of rs886403 in MUC21 displayed a shorter survival and higher recurrence risk when compared with TT carriers (overall survival (OS): hazard ratios (HR) 1.69, 95% confidence intervals (CI) 1.13-2.46, P = 0.01 and event-free survival (EFS): HR 1.99, 95% CI 1.38-2.84, P = 0.0002, respectively). The observed associations were more striking after stratification for tumor site (in patients with colon cancer, OS: HR 2.63, 95% CI 1.69-4.10, P < 0.0001 and EFS: HR 2.65, 95% CI 1.72-4.07, P < 0.0001). In contrast, rectal cancer cases carrying the CC genotype of rs4729655 in MUC17 displayed a longer survival (OS: HR 0.27, 95% CI 0.14-0.54, P = 0.0002) than those with the most common genotype. To our knowledge, this is the first study investigating miRSNPs potentially affecting miRNA binding to mucin genes and revealing their impact on CRC susceptibility or patients survival.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Carcinogenesis

ISSN

0143-3334

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

28-39

UT code for WoS article

000397050700005

EID of the result in the Scopus database

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