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Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00476439" target="_blank" >RIV/68378041:_____/17:00476439 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/17:10366580

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2017/8906027" target="_blank" >http://dx.doi.org/10.1155/2017/8906027</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2017/8906027" target="_blank" >10.1155/2017/8906027</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress

  • Original language description

    The aim of this study was to examine the effect of molecular hydrogen (H-2) on the healing of alkali-injured cornea. The effects of the solution of H-2 in phosphate buffered saline (PBS) or PBS alone topically applied on the alkali-injured rabbit cornea with 0.25M NaOH were investigated using immunohistochemical and biochemical methods. Central corneal thickness taken as an index of corneal hydration was measured with an ultrasonic pachymeter. Results show that irrigation of the damaged eyes with H-2 solution immediately after the injury and then within next five days renewed corneal transparency lost after the injury and reduced corneal hydration increased after the injury to physiological levels within ten days after the injury. In contrast, in injured corneas treated with PBS, the transparency of damaged corneas remained lost and corneal hydration elevated. Later results-on day 20 after the injury-showed that in alkali-injured corneas treated with H-2 solution the expression of proinflammatory cytokines, peroxynitrite, detected by nitrotyrosine residues (NT), and malondialdehyde (MDA) expressions were very low or absent compared to PBS treated injured corneas, where NT and MDA expressions were present. In conclusion, H-2 solution favorably influenced corneal healing after alkali injury via suppression of oxidative stress

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30207 - Ophthalmology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oxidative Medicine and Cellular Longevity

  • ISSN

    1942-0900

  • e-ISSN

  • Volume of the periodical

    2017

  • Issue of the periodical within the volume

    2017

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

  • UT code for WoS article

    000398254400001

  • EID of the result in the Scopus database

    2-s2.0-85016596650