Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00476439" target="_blank" >RIV/68378041:_____/17:00476439 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10366580
Result on the web
<a href="http://dx.doi.org/10.1155/2017/8906027" target="_blank" >http://dx.doi.org/10.1155/2017/8906027</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2017/8906027" target="_blank" >10.1155/2017/8906027</a>
Alternative languages
Result language
angličtina
Original language name
Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress
Original language description
The aim of this study was to examine the effect of molecular hydrogen (H-2) on the healing of alkali-injured cornea. The effects of the solution of H-2 in phosphate buffered saline (PBS) or PBS alone topically applied on the alkali-injured rabbit cornea with 0.25M NaOH were investigated using immunohistochemical and biochemical methods. Central corneal thickness taken as an index of corneal hydration was measured with an ultrasonic pachymeter. Results show that irrigation of the damaged eyes with H-2 solution immediately after the injury and then within next five days renewed corneal transparency lost after the injury and reduced corneal hydration increased after the injury to physiological levels within ten days after the injury. In contrast, in injured corneas treated with PBS, the transparency of damaged corneas remained lost and corneal hydration elevated. Later results-on day 20 after the injury-showed that in alkali-injured corneas treated with H-2 solution the expression of proinflammatory cytokines, peroxynitrite, detected by nitrotyrosine residues (NT), and malondialdehyde (MDA) expressions were very low or absent compared to PBS treated injured corneas, where NT and MDA expressions were present. In conclusion, H-2 solution favorably influenced corneal healing after alkali injury via suppression of oxidative stress
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30207 - Ophthalmology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oxidative Medicine and Cellular Longevity
ISSN
1942-0900
e-ISSN
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Volume of the periodical
2017
Issue of the periodical within the volume
2017
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
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UT code for WoS article
000398254400001
EID of the result in the Scopus database
2-s2.0-85016596650