Perspectives of Stem Cell-Based Therapy for Age-Related Retinal Degenerative Diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00478187" target="_blank" >RIV/68378041:_____/17:00478187 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10366586
Result on the web
<a href="http://dx.doi.org/10.3727/096368917X695317" target="_blank" >http://dx.doi.org/10.3727/096368917X695317</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3727/096368917X695317" target="_blank" >10.3727/096368917X695317</a>
Alternative languages
Result language
angličtina
Original language name
Perspectives of Stem Cell-Based Therapy for Age-Related Retinal Degenerative Diseases
Original language description
Retinal degenerative diseases, which include age-related macular degeneration, retinitis pigmentosa, diabetic retinopathy, and glaucoma, mostly affect the elderly population and are the most common cause of decreased quality of vision or even blindness. So far, there is no satisfactory treatment protocol to prevent, stop, or cure these disorders. A great hope and promise for patients suffering from retinal diseases is represented by stem cell-based therapy that could replace diseased or missing retinal cells and support regeneration. In this respect, mesenchymal stem cells (MSCs) that can be obtained from the particular patient and used as autologous cells have turned out to be a promising stem cell type for treatment. Here we show that MSCs can differentiate into cells expressing markers of retinal cells, inhibit production of pro-inflammatory cytokines by retinal tissue, and produce a number of growth and neuroprotective factors for retinal regeneration. All of these properties make MSCs a prospective cell type for cell-based therapy of age-related retinal degenerative diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30207 - Ophthalmology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Transplantation
ISSN
0963-6897
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
1538-1541
UT code for WoS article
000414907000006
EID of the result in the Scopus database
2-s2.0-85034031933