Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00480925" target="_blank" >RIV/68378041:_____/17:00480925 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10364004 RIV/00216208:11140/17:10364004 RIV/00064165:_____/17:10364004
Result on the web
<a href="http://dx.doi.org/10.1016/S1474-4422(17)30327-7" target="_blank" >http://dx.doi.org/10.1016/S1474-4422(17)30327-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S1474-4422(17)30327-7" target="_blank" >10.1016/S1474-4422(17)30327-7</a>
Alternative languages
Result language
angličtina
Original language name
Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis
Original language description
We identified and replicated 13 new risk loci for restless legs syndrome and confirmed the previously identified six risk loci. MEIS1 was confirmed as the strongest genetic risk factor for restless legs syndrome (odds ratio 1.92, 95% CI 1.85–1.99). Gene prioritisation, enrichment, and genetic correlation analyses showed that identified pathways were related to neurodevelopment and highlighted genes linked to axon guidance (associated with SEMA6D), synapse formation (NTNG1), and neuronal specification (HOXB cluster family and MYT1). Identification of new candidate genes and associated pathways will direct future functional research. Advances in understanding of the molecular mechanisms that underlie restless legs syndrome could lead to new treatment options. We focused on common variants, thus, additional studies are needed to dissect the roles of rare and structural variations.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LO1503" target="_blank" >LO1503: BIOMEDIC</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Lancet Neurology
ISSN
1474-4422
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
898-907
UT code for WoS article
000412663200012
EID of the result in the Scopus database
2-s2.0-85031737266