Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F17%3A00481044" target="_blank" >RIV/68378041:_____/17:00481044 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10364570 RIV/00216208:11140/17:10364570
Result on the web
<a href="http://dx.doi.org/10.1186/s12876-017-0659-9" target="_blank" >http://dx.doi.org/10.1186/s12876-017-0659-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12876-017-0659-9" target="_blank" >10.1186/s12876-017-0659-9</a>
Alternative languages
Result language
angličtina
Original language name
Association between polymorphisms of TAS2R16 and susceptibility to colorectal cancer
Original language description
Background: Genetics plays an important role in the susceptibility to sporadic colorectal cancer (CRC). In the last 10 years genome-wide association studies (GWAS) have identified over 40 independent low penetrance polymorphic variants. However, these loci only explain around 1-4% of CRC heritability, highlighting the dire need of identifying novel risk loci. In this study, we focused our attention on the genetic variability of the TAS2R16 gene, encoding for one of the bitter taste receptors that selectively binds to salicin, a natural antipyretic that resembles aspirin. Given the importance of inflammation in CRC, we tested whether polymorphic variants in this gene could affect the risk of developing this neoplasia hypothesizing a role of TAS2R16 in modulating chronic inflammation within the gut. nnMethods: We performed an association study using 6 tagging SNPs, (rs860170, rs978739, rs1357949, rs1525489, rs6466849, rs10268496) that cover all TAS2R16 genetic variability. The study was carried out on 1902 CRC cases and 1532 control individuals from four European countries. nnResults: We did not find any statistically significant association between risk of developing CRC and selected SNPs. However, after stratification by histology (colon vs. rectum) we found that rs1525489 was associated with increased risk of rectal cancer with a (P-trend of = 0.0071). nnConclusions: Our data suggest that polymorphisms within TAS2R16 gene do not have a strong influence on colon cancer susceptibility, but a possible role in rectal cancer should be further evaluated in larger cohorts.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Gastroenterology
ISSN
1471-230X
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
sep
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
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UT code for WoS article
000410805800001
EID of the result in the Scopus database
2-s2.0-85029413175