The Paper that Restarted Modern Central Nervous System Axon Regeneration Research
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00492416" target="_blank" >RIV/68378041:_____/18:00492416 - isvavai.cz</a>
Result on the web
<a href="https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(18)30061-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223618300614%3Fshowall%3Dtrue" target="_blank" >https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(18)30061-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223618300614%3Fshowall%3Dtrue</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tins.2018.02.012" target="_blank" >10.1016/j.tins.2018.02.012</a>
Alternative languages
Result language
angličtina
Original language name
The Paper that Restarted Modern Central Nervous System Axon Regeneration Research
Original language description
Spinal cord repair research appeared to have run out of new ideas in the 1970s. In a 1981 paper, the Aguayo Laboratory revisited an experiment by Tello and Cajal that suggestedthat central nervous system (CNS) axons could regenerate into peripheral nerve grafts. Using modern axon tracing methods, David and Aguayo showed that axons from neurons in the spinal cord could regenerate for long distances within peripheral nervous system (PNS) grafts, but not back into the CNS. This proved that damaged CNS tissue is inhibitory to axon regeneration while PNS tissue is permissive. The experiment sparked a research revival, leading to the identification of many inhibitory molecules that block axon growth in the mature CNS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Neurosciences
ISSN
0166-2236
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
5
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
239-242
UT code for WoS article
000430989700001
EID of the result in the Scopus database
2-s2.0-85044332280