Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic - a retrospective study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00493234" target="_blank" >RIV/68378041:_____/18:00493234 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s12884-018-1981-0" target="_blank" >http://dx.doi.org/10.1186/s12884-018-1981-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12884-018-1981-0" target="_blank" >10.1186/s12884-018-1981-0</a>

Result language

angličtina

Original language name

Long-term significant seasonal differences in the numbers of new-borns with an orofacial cleft in the Czech Republic - a retrospective study

Original language description

Choosing the optimal season for conception is a part of family planning since it can positively influence the pregnancy outcome. The aim of our paper was to search for possible seasonal differences in the numbers of new-borns with an orofacial cleft and thus for a period of conception that can increase the risk of orofacial cleft development.Mean monthly numbers of live births in the Bohemia region of the Czech Republic during the years 1964-2000 were compared within a group of 5619 new-borns with various types of orofacial clefts and the control group of 3,080,891 new-borns.The control group exhibited regular seasonal variation in the monthly numbers of new-borns: significantly more babies born during March-May and fewer babies born during October-December. Similar natural seasonal variation was also found in the group of babies with an orofacial cleft. However, after subdividing the cleft group according to gender and cleft type, in comparison to controls, significant differences appeared in the number of new-born girls with cleft lip during January-March and in the number of boys born with cleft palate in April - May.We found significant differences from controls in the number of new-born girls with CL and boys with CP, whose dates of birth correspond to conception from April to August and to the estimated prenatal critical period for cleft formation from May to October. The latter period includes the warm season, when various injurious physical, chemical and biological factors may act on a pregnant woman.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30214 - Obstetrics and gynaecology

Project

<a href="/en/project/GB14-37368G" target="_blank" >GB14-37368G: Centre of orofacial development and regeneration</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Pregnancy and Childbirth

ISSN

1471-2393

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

aug 28

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

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UT code for WoS article

000443335900001

EID of the result in the Scopus database

2-s2.0-85052509636