The Effect of Complex Acoustic Environment during Early Development on the Responses of Auditory Cortex Neurons in Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F18%3A00493481" target="_blank" >RIV/68378041:_____/18:00493481 - isvavai.cz</a>

Alternative codes found

RIV/71226401:_____/18:N0100010

Result on the web

<a href="http://dx.doi.org/10.1016/j.neuroscience.2017.11.049" target="_blank" >http://dx.doi.org/10.1016/j.neuroscience.2017.11.049</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuroscience.2017.11.049" target="_blank" >10.1016/j.neuroscience.2017.11.049</a>

Result language

angličtina

Original language name

The Effect of Complex Acoustic Environment during Early Development on the Responses of Auditory Cortex Neurons in Rats

Original language description

Acoustical environment plays an important role during the maturation of the auditory system. It has been shown that the sensory inputs to the developing centres influence the development of the structure of projections, neuronal responsiveness, excitatory-inhibitory balance, or tonotopical arrangement, throughout the auditory pathway. Our previous study (Bures et al., 2014) showed that rats reared in a complex acoustic environment (spectrally and temporally modulated sound reinforced by an active behavioural paradigm with a positive feedback) exhibit permanently improved response characteristics of the inferior colliculus (IC) neurons. Extending these results, the current work provides evidence that the changes occur also at the level of auditory cortex (AC). In particular, the enriched animals have lower excitatory thresholds, sharper frequency selectivity, and a lower proportion of non-monotonic rate-intensity functions. In contrast to the changes observed in the IC, the cortical neurons of enriched animals have lower response magnitudes. In addition, the enrichment changed the AC responsiveness to frequency-modulated and also to a lesser extent, amplitude-modulated stimuli. Significantly, the alterations span the entire hearing range and may be regarded as general and not directly linked to the characteristics of the acoustical stimulation. Furthermore, these developmentally induced changes are permanent and detectable in adulthood. The findings indicate that an acoustically enriched environment during the critical period of postnatal development influences basic properties of neuronal receptive fields in the AC, which may have implications for the ability to detect and discriminate sounds.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/GBP304%2F12%2FG069" target="_blank" >GBP304/12/G069: Project of excellence in the field of neuroscience</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroscience

ISSN

0306-4522

e-ISSN

—

Volume of the periodical

371

Issue of the periodical within the volume

feb 10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

8

Pages from-to

221-228

UT code for WoS article

000425876200018

EID of the result in the Scopus database

2-s2.0-85039170840