The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00508394" target="_blank" >RIV/68378041:_____/19:00508394 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1582770" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1582770</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10715762.2019.1582770" target="_blank" >10.1080/10715762.2019.1582770</a>
Alternative languages
Result language
angličtina
Original language name
The preventive and therapeutic effects of molecular hydrogen in ocular diseases and injuries where oxidative stress is involved
Original language description
Oxidative stress initiates, accompanies and contributes to the development of several human diseases and injuries, including ocular diseases. Reactive oxygen species (ROS) can generate oxidative stress via excessive ROS production and/or decreased physiologically occurring antioxidants. To replace these weakened antioxidants, substances with effective antioxidant properties are needed in order to suppress oxidative stress and enable healing. Molecular hydrogen (H-2) is very suitable for this purpose due to its unique properties. H-2 is the only antioxidant that crosses the blood-brain and blood-ocular barriers. It quickly penetrates through tissue due to its small molecular size and effectively removes ROS, mainly hydroxyl radicals and peroxynitrite. Apart from its antioxidant effects, H-2 also displays anti-inflammatory, antiapoptotic, cytoprotective and mitohormetic properties. A significant advantage of H-2 is its nontoxicity, even when applied at high concentrations. In this review, we present the results of studies utilising H-2 in the treatment of ocular diseases involving oxidative stress. These results, obtained in experimental animals as well as in human clinical studies, show that the suppression of oxidative stress by H-2 treatment leads to the prevention or improvement of ocular diseases. In severe degenerative diseases, H-2 slows disease progression.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30207 - Ophthalmology
Result continuities
Project
<a href="/en/project/LO1309" target="_blank" >LO1309: Cell Therapy and Tissue Repair</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Free Radical Research
ISSN
1071-5762
e-ISSN
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Volume of the periodical
53
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
237-247
UT code for WoS article
000463483900001
EID of the result in the Scopus database
2-s2.0-85065655228