The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00508423" target="_blank" >RIV/68378041:_____/19:00508423 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/19:10394497 RIV/68407700:21220/19:00332151 RIV/68407700:21460/19:00332151 RIV/00216208:11120/19:43918334
Result on the web
<a href="https://www.nature.com/articles/s41598-019-44141-2" target="_blank" >https://www.nature.com/articles/s41598-019-44141-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-019-44141-2" target="_blank" >10.1038/s41598-019-44141-2</a>
Alternative languages
Result language
angličtina
Original language name
The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
Original language description
We investigated the effect of a Multiwave Locked System laser (with a simultaneous 808 nm continuous emission and 905 nm pulse emission) on the spinal cord after spinal cord injury (SCI) in rats. The functional recovery was measured by locomotor tests (BBB, Beam walking, MotoRater) and a sensitivity test (Plantar test). The locomotor tests showed a significant improvement of the locomotor functions of the rats after laser treatment from the first week following lesioning, compared to the controls. The laser treatment significantly diminished thermal hyperalgesia after SCI as measured by the Plantar test. The atrophy of the soleus muscle was reduced in the laser treated rats. The histopathological investigation showed a positive effect of the laser therapy on white and gray matter sparing. Our data suggests an upregulation of M2 macrophages in laser treated animals by the increasing number of double labeled CD68+/CD206+ cells in the cranial and central parts of the lesion, compared to the control animals. A shift in microglial/macrophage polarization was confirmed by gene expression analysis by significant mRNA downregulation of Cd86 (marker of inflammatory M1), and non-significant upregulation of Arg1 (marker of M2). These results demonstrated that the combination of 808 nm and 905 nm wavelength light is a promising non-invasive therapy for improving functional recovery and tissue sparing after SCI.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
may.
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
7660
UT code for WoS article
000468423600032
EID of the result in the Scopus database
2-s2.0-85066087002