DNA repair capacity and response to treatment of colon cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00518156" target="_blank" >RIV/68378041:_____/19:00518156 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/19:10397883 RIV/00216208:11110/19:10397883 RIV/00216208:11120/19:43919140 RIV/00064190:_____/19:N0000021
Result on the web
<a href="https://www.futuremedicine.com/doi/10.2217/pgs-2019-0070" target="_blank" >https://www.futuremedicine.com/doi/10.2217/pgs-2019-0070</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2217/pgs-2019-0070" target="_blank" >10.2217/pgs-2019-0070</a>
Alternative languages
Result language
angličtina
Original language name
DNA repair capacity and response to treatment of colon cancer
Original language description
DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair also plays a substantial role in response to chemotherapeutics: rapidly dividing colon cancer cells, vulnerable to DNA-damaging agents and overcoming DNA repair, undergo cell death. DNA repair capacity represents a complex biomarker, integrating gene variants, gene expressions, the stability of gene products, the effect of inhibitors/stimulators, lifestyle and environmental factors. Here, we discuss DNA repair capacity in sporadic colon cancer, a frequent malignancy worldwide, in relation to tumor heterogeneity, prognosis and prediction, measurements in surrogate and target tissues and suggest important tasks to be addressed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pharmacogenomics
ISSN
1462-2416
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
17
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1225-1233
UT code for WoS article
000507615600005
EID of the result in the Scopus database
2-s2.0-85075885615