CDC20 associated with cancer metastasis and novel mushroom-derived CDC20 inhibitors with antimetastatic activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00518845" target="_blank" >RIV/68378041:_____/19:00518845 - isvavai.cz</a>

Result on the web

<a href="https://www.spandidos-publications.com/10.3892/ijo.2019.4791" target="_blank" >https://www.spandidos-publications.com/10.3892/ijo.2019.4791</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ijo.2019.4791" target="_blank" >10.3892/ijo.2019.4791</a>

Result language

angličtina

Original language name

CDC20 associated with cancer metastasis and novel mushroom-derived CDC20 inhibitors with antimetastatic activity

Original language description

Aberrant expression of cell division cycle 20 (CDC20) is associated with malignant progression and poor prognosis in various types of cancer. The development of specific CDC20 inhibitors may be a novel strategy for the treatment of cancer with elevated expression of CDC20. The aim of the current study was to elucidate the role of CDC20 in cancer cell invasiveness and to identify novel natural inhibitors of CDC20. The authors found that CDC20 knockdown inhibited the migration of chemoresistant PANC-1 pancreatic cancer cells and the metastatic MDA-MB-231 breast cancer cell line. By contrast, the overexpression of CDC20 by plasmid transfection promoted the metastasizing capacities of the PANC-1 cells and MCF-7 breast cancer cells. It was also identified that a triterpene mixture extracted from the mushroom Poria cocos (PTE), purified triterpenes dehydropachymic acid, and polyporenic acid C (PPAC) downregulated the expression of CDC20 in PANC-1 cells dose-dependently. Migration was also suppressed by PTE and PPAC in a dose-dependent manner, which was consistent with expectations. Taken together, the present study is the first, to the best of our knowledge, to demonstrate that CDC20 serves an important role in cancer metastasis and that triterpenes from P. cocos inhibit the migration of pancreatic cancer cells associated with CDC20. Further investigations are in progress to investigate the specific mechanism associated with CDC20 and these triterpenes, which may have future potential use as natural agents in the treatment of metastatic cancer.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30101 - Human genetics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Oncology

ISSN

1019-6439

e-ISSN

—

Volume of the periodical

54

Issue of the periodical within the volume

6

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

2250-2256

UT code for WoS article

000477432000030

EID of the result in the Scopus database

2-s2.0-85064874011