Distant Metastasis in Colorectal Cancer Patients-Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539078" target="_blank" >RIV/68378041:_____/20:00539078 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/20:10413339 RIV/00216208:11150/20:10413339 RIV/00179906:_____/20:10413339 RIV/00216208:11110/20:10413339

Result on the web

<a href="https://www.mdpi.com/1422-0067/21/15/5255" target="_blank" >https://www.mdpi.com/1422-0067/21/15/5255</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms21155255" target="_blank" >10.3390/ijms21155255</a>

Result language

angličtina

Original language name

Distant Metastasis in Colorectal Cancer Patients-Do We Have New Predicting Clinicopathological and Molecular Biomarkers? A Comprehensive Review

Original language description

Colorectal cancer (CRC) remains a serious health problem worldwide. Approximately half of patients will develop distant metastasis after CRC resection, usually with very poor prognosis afterwards. Because patient performance after distant metastasis surgery remains very heterogeneous, ranging from death within 2 years to a long-term cure, there is a clinical need for a precise risk stratification of patients to aid pre- and post-operative decisions. Furthermore, around 20% of identified CRC cases are at IV stage disease, known as a metastatic CRC (mCRC). In this review, we overview possible molecular and clinicopathological biomarkers that may provide prognostic and predictive information for patients with distant metastasis. These may comprise sidedness of the tumor, molecular profile and epigenetic characteristics of the primary tumor and arising metastatic CRC, and early markers reflecting cancer cell resistance in mCRC and biomarkers identified from transcriptome. This review discusses current stage in employment of these biomarkers in clinical practice as well as summarizes current experience in identifying predictive biomarkers in mCRC treatment.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NV19-09-00237" target="_blank" >NV19-09-00237: The clinicopathological and molecular factors detected in metastases, predicting of treatment response in colon cancer patients.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

—

Volume of the periodical

21

Issue of the periodical within the volume

15

Country of publishing house

CH - SWITZERLAND

Number of pages

24

Pages from-to

5255

UT code for WoS article

000559118000001

EID of the result in the Scopus database

2-s2.0-85088811201