Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539298" target="_blank" >RIV/68378041:_____/20:00539298 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/20:10405230 RIV/00216208:11140/20:10405230
Result on the web
<a href="https://www.nature.com/articles/s41467-020-14389-8" target="_blank" >https://www.nature.com/articles/s41467-020-14389-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-020-14389-8" target="_blank" >10.1038/s41467-020-14389-8</a>

Result language
angličtina
Original language name
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis
Original language description
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies, however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value=0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value=0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers. Physical activity has been linked to lower risks of colorectal and breast cancer. Here, the authors present a Mendelian randomisation analysis supporting a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30302 - Epidemiology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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