Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539309" target="_blank" >RIV/68378041:_____/20:00539309 - isvavai.cz</a>
Alternative codes found
RIV/00843989:_____/20:E0108445
Result on the web
<a href="https://www.nature.com/articles/s41375-019-0619-1" target="_blank" >https://www.nature.com/articles/s41375-019-0619-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41375-019-0619-1" target="_blank" >10.1038/s41375-019-0619-1</a>
Alternative languages
Result language
angličtina
Original language name
Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance
Original language description
Multiple myeloma (MM) is caused by a clonal proliferation of malignant plasma cells in the bone marrow preceded by monoclonal gammopathy of unknown signifikance (MGUS). MGUS can also progress to immunoglobulin light chain amyloidosis (amyloidosis AL). While genome-wide association studies (GWAS)-based germline genetics of each of these have been published, it is not well known to what extent their genetic profiles may be shared. Meta analysis combining large GWAS datasets of the three dyscrasias show strong evidence on shared germline genetics for the three plasma cell dyscrasias.nHowever, future studies are needed to decipher the functional basis of the risk SNPs. The most significant association at chromosome 7p15.3 (rs75341503) has been identified as a binding site for IRF4 and may offer a therapeutic target for the three dyscrasiasn
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30302 - Epidemiology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia
ISSN
0887-6924
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
1187-1191
UT code for WoS article
000522798800024
EID of the result in the Scopus database
2-s2.0-85074865437