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Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539309" target="_blank" >RIV/68378041:_____/20:00539309 - isvavai.cz</a>

  • Alternative codes found

    RIV/00843989:_____/20:E0108445

  • Result on the web

    <a href="https://www.nature.com/articles/s41375-019-0619-1" target="_blank" >https://www.nature.com/articles/s41375-019-0619-1</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/s41375-019-0619-1" target="_blank" >10.1038/s41375-019-0619-1</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Eight novel loci implicate shared genetic etiology in multiple myeloma, AL amyloidosis, and monoclonal gammopathy of unknown significance

  • Original language description

    Multiple myeloma (MM) is caused by a clonal proliferation of malignant plasma cells in the bone marrow preceded by monoclonal gammopathy of unknown signifikance (MGUS). MGUS can also progress to immunoglobulin light chain amyloidosis (amyloidosis AL). While genome-wide association studies (GWAS)-based germline genetics of each of these have been published, it is not well known to what extent their genetic profiles may be shared. Meta analysis combining large GWAS datasets of the three dyscrasias show strong evidence on shared germline genetics for the three plasma cell dyscrasias.nHowever, future studies are needed to decipher the functional basis of the risk SNPs. The most significant association at chromosome 7p15.3 (rs75341503) has been identified as a binding site for IRF4 and may offer a therapeutic target for the three dyscrasiasn

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30302 - Epidemiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Leukemia

  • ISSN

    0887-6924

  • e-ISSN

  • Volume of the periodical

    34

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    5

  • Pages from-to

    1187-1191

  • UT code for WoS article

    000522798800024

  • EID of the result in the Scopus database

    2-s2.0-85074865437