Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00539948" target="_blank" >RIV/68378041:_____/20:00539948 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/20:10413828

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fphys.2020.00753/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fphys.2020.00753/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphys.2020.00753" target="_blank" >10.3389/fphys.2020.00753</a>

Result language

angličtina

Original language name

Development of the Vestibular Lamina in Human Embryos: Morphogenesis and Vestibule Formation

Original language description

The vestibular lamina (VL) is a transient developmental structure that forms the lip furrow, creating a gap between the lips/cheeks and teeth (oral vestibule). Surprisingly, little is known about the development of the VL and its relationship to the adjacent dental lamina (DL), which forms the teeth. In some congenital disorders, such as Ellis-van Creveld (EVC) syndrome, development of the VL is disrupted and multiple supernumerary frenula form, physically linking the lips and teeth. Here, we assess the normal development of the VL in human embryos from 6.5 (CS19) to 13 weeks of development, showing the close relationship between the VL and DL, from initiation to differentiation. In the anterior lower region, the two structures arise from the same epithelial thickening. The VL then undergoes complex morphogenetic changes during development, forming a branched structure that separates to create the vestibule. Changing expression of keratins highlight the differentiation patterns in the VL, with fissure formation linked to the onset of filaggrin. Apoptosis is involved in removal of the central portion of the VL to create a broad furrow between the future cheek and gum. This research forms an essential base to further explore developmental defects in this part of the oral cavity.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10605 - Developmental biology

Project

<a href="/en/project/GA18-04859S" target="_blank" >GA18-04859S: Fate decisions in the dental placode: an investigation into the signalling factors that determine cell fate decisions in the early oral cavity</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in physiology

ISSN

1664-042X

e-ISSN

—

Volume of the periodical

11

Issue of the periodical within the volume

jul.

Country of publishing house

CH - SWITZERLAND

Number of pages

10

Pages from-to

753

UT code for WoS article

000559261900001

EID of the result in the Scopus database

2-s2.0-85088824552