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Polysubstituted pyrimidines inhibiting the formation of prostaglandin E2, a method of production thereof and use thereof

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00541997" target="_blank" >RIV/68378041:_____/20:00541997 - isvavai.cz</a>

  • Alternative codes found

    RIV/61388963:_____/20:00541997

  • Result on the web

    <a href="https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20201022&DB=&locale=en_EP&CC=AU&NR=2018273599B2&KC=B2&ND=4" target="_blank" >https://worldwide.espacenet.com/publicationDetails/originalDocument?FT=D&date=20201022&DB=&locale=en_EP&CC=AU&NR=2018273599B2&KC=B2&ND=4</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Polysubstituted pyrimidines inhibiting the formation of prostaglandin E2, a method of production thereof and use thereof

  • Original language description

    The invention describes the pyrimidine-based compounds of the general formula I. Described compounds lower the production of the prostaglandin E2. In concentrations lowering production of this factor by 50%, these compounds have no negative effect on the cell viability and they are not cytotoxic. Furthermore, the method of production of the compounds of the general formula I is provided. A pharmaceutical composition comprising the polysubstituted pyrimidines according to the invention and the use of these compounds for the treatment of the inflammatory diseases are also provided.

  • Czech name

  • Czech description

Classification

  • Type

    P - Patent

  • CEP classification

  • OECD FORD branch

    30107 - Medicinal chemistry

Result continuities

  • Project

    <a href="/en/project/TE01020028" target="_blank" >TE01020028: Center for Development of Original Drugs</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Patent/design ID

    AU2018273599

  • Publisher

    AU001 -

  • Publisher name

    IP Australia

  • Place of publication

    Phillip ACT

  • Publication country

    AU - AUSTRALIA

  • Date of acceptance

    Oct 22, 2020

  • Owner name

    Ústav organické chemie a biochemie AV ČR, v. v. i. - Ústav experimentální medicíny AV ČR, v. v. i

  • Method of use

    A - Výsledek využívá pouze poskytovatel

  • Usage type

    A - K využití výsledku jiným subjektem je vždy nutné nabytí licence