Iron-oxide minerals in the human tissues
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F20%3A00560645" target="_blank" >RIV/68378041:_____/20:00560645 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s10534-020-00232-6" target="_blank" >https://link.springer.com/article/10.1007/s10534-020-00232-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10534-020-00232-6" target="_blank" >10.1007/s10534-020-00232-6</a>
Alternative languages
Result language
angličtina
Original language name
Iron-oxide minerals in the human tissues
Original language description
Iron is critically important and highly regulated trace metal in the human body. However, in its free ion form, it is known to be cytotoxic, therefore, it is bound to iron storing protein, ferritin. Ferritin is a key regulator of body iron homeostasis able to form various types of minerals depending on the tissue environment. Each mineral, e.g. magnetite, maghemite, goethite, akaganeite or hematite, present in the ferritin core carry different characteristics possibly affecting cells in the tissue. In specific cases, it can lead to disease development. Widely studied connection with neurodegenerative conditions is widely studied, including Alzheimer disease. Although the exact ferritin structure and its distribution throughout a human body are still not fully known, many studies have attempted to elucidate the mechanisms involved in its regulation and pathogenesis. In this review, we try to summarize the iron uptake into the body. Next, we discuss the known occurrence of ferritin in human tissues. Lastly, we also examine the formation of iron oxides and their involvement in brain functions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biometals
ISSN
0966-0844
e-ISSN
1572-8773
Volume of the periodical
33
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
1-13
UT code for WoS article
000508702600001
EID of the result in the Scopus database
2-s2.0-85078130566