Effect of Kv3 channel modulators on auditory temporal resolution in aged Fischer 344 rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00551560" target="_blank" >RIV/68378041:_____/21:00551560 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43920873
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S037859552030410X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S037859552030410X?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.heares.2020.108139" target="_blank" >10.1016/j.heares.2020.108139</a>
Alternative languages
Result language
angličtina
Original language name
Effect of Kv3 channel modulators on auditory temporal resolution in aged Fischer 344 rats
Original language description
AUT0 0 063 and AUT00202 are novel pharmaceutical modulators of the Kv3 subfamily of voltage-gated K + channels. Kv3.1 channels, which control fast firing of many central auditory neurons, have been shown to decline with age and this may contribute to age-related deficits in central auditory processing. In the present study, the effects of the two novel compounds that specifically modulate Kv3 channels on au-ditory temporal processing were examined in aged (19-25-month-old) and young-adult (3-5 month-old) Fischer 344 rats (F344) using a behavioral gap-prepulse inhibition (gap-PPI) paradigm. The acoustic star-tle response (ASR) and its inhibition induced by a gap in noise were measured before and after drug ad-ministration. Hearing thresholds in tested rats were evaluated by the auditory brainstem response (ABR). Aged F344 rats had significantly higher ABR thresholds, lower amplitudes of ASR, and weaker gap-PPI compared with young-adult rats. No influence of AUT0 0 063 and AUT0 0202 administration was observed on ABR hearing thresholds in rats of both age groups. AUT0 0 063 and AUT00202 had suppressive effect on ASR of F344 rats that was more pronounced with AUT0 0 063. The degree of suppression depended on the dose and age of the rats. Both compounds significantly improved the gap-PPI performance in gap detection tests in aged rats. These results indicate that AUT0 0 063 and AUT0 0202 may influence intrinsic firing properties of neurons in the central auditory system of aged animals and have the potential to treat aged-related hearing disorders.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA18-09692S" target="_blank" >GA18-09692S: Functional changes of the auditory system associated with auditory experience and aging</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hearing Research
ISSN
0378-5955
e-ISSN
1878-5891
Volume of the periodical
401
Issue of the periodical within the volume
mar.
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
108139
UT code for WoS article
000632467500001
EID of the result in the Scopus database
2-s2.0-85097896615