Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00552048" target="_blank" >RIV/68378041:_____/21:00552048 - isvavai.cz</a>
Alternative codes found
RIV/00064173:_____/20:N0000007 RIV/00216208:11120/21:43921104 RIV/00216208:11140/21:10422537 RIV/00216208:11110/21:10422537 RIV/00098892:_____/21:N0000105
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ijc.33475" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ijc.33475</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.33475" target="_blank" >10.1002/ijc.33475</a>

Result language
angličtina
Original language name
Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility
Original language description
Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 x 10(-9)). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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