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Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00552048" target="_blank" >RIV/68378041:_____/21:00552048 - isvavai.cz</a>

  • Alternative codes found

    RIV/00064173:_____/20:N0000007 RIV/00216208:11120/21:43921104 RIV/00216208:11140/21:10422537 RIV/00216208:11110/21:10422537 RIV/00098892:_____/21:N0000105

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/10.1002/ijc.33475" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ijc.33475</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/ijc.33475" target="_blank" >10.1002/ijc.33475</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genome-wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility

  • Original language description

    Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cancer-related cause of death by 2030. Identifying novel risk factors, including genetic risk loci, could be instrumental in risk stratification and implementation of prevention strategies. Long noncoding RNAs (lncRNAs) are involved in regulation of key biological processes, and the possible role of their genetic variability has been unexplored so far. Combining genome wide association studies and functional data, we investigated the genetic variability in all lncRNAs. We analyzed 9893 PDAC cases and 9969 controls and identified a genome-wide significant association between the rs7046076 SNP and risk of developing PDAC (P = 9.73 x 10(-9)). This SNP is located in the NONHSAG053086.2 (lnc-SMC2-1) gene and the risk allele is predicted to disrupt the binding of the lncRNA with the micro-RNA (miRNA) hsa-mir-1256 that regulates several genes involved in cell cycle, such as CDKN2B. The CDKN2B region is pleiotropic and its genetic variants have been associated with several human diseases, possibly though an imperfect interaction between lncRNA and miRNA. We present a novel PDAC risk locus, supported by a genome-wide statistical significance and a plausible biological mechanism.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10603 - Genetics and heredity (medical genetics to be 3)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    International Journal of Cancer

  • ISSN

    0020-7136

  • e-ISSN

    1097-0215

  • Volume of the periodical

    148

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

    2779-2788

  • UT code for WoS article

    000614216300001

  • EID of the result in the Scopus database

    2-s2.0-85100380577