Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00552705" target="_blank" >RIV/68378041:_____/21:00552705 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/21:10431683 RIV/00216208:11120/21:43922182 RIV/00216208:11110/21:10431683 RIV/00098892:_____/21:N0000081 RIV/61989592:15110/21:73608694
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fgene.2021.693933/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fgene.2021.693933/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fgene.2021.693933" target="_blank" >10.3389/fgene.2021.693933</a>
Alternative languages
Result language
angličtina
Original language name
Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk
Original language description
Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC, therefore, more progress is needed to find the missing ones. We aimed at identifying single nucleotide polymorphisms (SNPs) affecting PC risk through effects on micro-RNA (miRNA) function. We searched in silico the genome for SNPs in miRNA seed sequences or 3 prime untranslated regions (3'UTRs) of miRNA target genes. Genome-wide association data of PC cases and controls from the Pancreatic Cancer Cohort (PanScan) Consortium and the Pancreatic Cancer Case-Control (PanC4) Consortium were re-analyzed for discovery, and genotyping data from two additional consortia (PanGenEU and PANDoRA) were used for replication, for a total of 14,062 cases and 11,261 controls. None of the SNPs reached genome-wide significance in the meta-analysis, but for three of them the associations were in the same direction in all the study populations and showed lower value of p in the meta-analyses than in the discovery phase. Specifically, rs7985480 was consistently associated with PC risk (OR = 1.12, 95% CI 1.07-1.17, p = 3.03 x 10(-6) in the meta-analysis). This SNP is in linkage disequilibrium (LD) with rs2274048, which modulates binding of various miRNAs to the 3'UTR of UCHL3, a gene involved in PC progression. In conclusion, our results expand the knowledge of the genetic PC risk through miRNA-related SNPs and show the usefulness of functional prioritization to identify genetic polymorphisms associated with PC risk.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in genetics
ISSN
1664-8021
e-ISSN
1664-8021
Volume of the periodical
12
Issue of the periodical within the volume
aug.
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
693933
UT code for WoS article
000698452600001
EID of the result in the Scopus database
2-s2.0-85114813099