Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00552788" target="_blank" >RIV/68378041:_____/21:00552788 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11140/21:10434869 RIV/00216208:11110/21:10434869

Result on the web

<a href="https://www.mdpi.com/2072-6643/13/11/4164" target="_blank" >https://www.mdpi.com/2072-6643/13/11/4164</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu13114164" target="_blank" >10.3390/nu13114164</a>

Result language

angličtina

Original language name

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

Original language description

Salicylic acid (SA) has observationally been shown to decrease colorectal cancer (CRC) risk. Aspirin (acetylsalicylic acid, that rapidly deacetylates to SA) is an effective primary and secondary chemopreventive agent. Through a Mendelian randomization (MR) approach, we aimed to address whether levels of SA affected CRC risk, stratifying by aspirin use. A two-sample MR analysis was performed using GWAS summary statistics of SA (INTERVAL and EPIC-Norfolk, N = 14,149) and CRC (CCFR, CORECT, GECCO and UK Biobank, 55,168 cases and 65,160 controls). The DACHS study (4410 cases and 3441 controls) was used for replication and stratification of aspirin-use. SNPs proxying SA were selected via three methods: (1) functional SNPs that influence the activity of aspirin-metabolising enzymes, (2) pathway SNPs present in enzymes' coding regions and (3) genome-wide significant SNPs. We found no association between functional SNPs and SA levels. The pathway and genome-wide SNPs showed no association between SA and CRC risk (OR: 1.03, 95% CI: 0.84-1.27 and OR: 1.08, 95% CI: 0.86-1.34, respectively). Results remained unchanged upon aspirin use stratification. We found little evidence to suggest that an SD increase in genetically predicted SA protects against CRC risk in the general population and upon stratification by aspirin use.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

<a href="/en/project/NU21-07-00247" target="_blank" >NU21-07-00247: Concept of liquid biopsy in mapping of microRNA and oncogenic KRAS mutations for early diagnosis and risk assessment of pancreatic cancer.</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nutrients

ISSN

2072-6643

e-ISSN

2072-6643

Volume of the periodical

13

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

21

Pages from-to

4164

UT code for WoS article

000732628500001

EID of the result in the Scopus database

2-s2.0-85119379732