Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00560832" target="_blank" >RIV/68378041:_____/21:00560832 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11310/21:10436465 RIV/60461373:22330/21:43923678 RIV/00027022:_____/22:1139

Result on the web

<a href="https://www.mdpi.com/2410-3888/6/4/70" target="_blank" >https://www.mdpi.com/2410-3888/6/4/70</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/fishes6040070" target="_blank" >10.3390/fishes6040070</a>

Result language

angličtina

Original language name

Evolution of the Parvalbumin Genes in Teleost Fishes after the Whole-Genome Duplication

Original language description

Parvalbumin is considered a major fish allergen. Here, we report the molecular evolution of the parvalbumin genes in bony fishes based on 19 whole genomes and 70 transcriptomes. We found unexpectedly high parvalbumin diversity in teleosts, three main gene types (pvalb-alpha, pvalb-beta 1, and pvalb-beta 2, including oncomodulins) originated at the onset of vertebrates. Teleosts have further multiplied the parvalbumin gene repertoire up to nine ancestral copies-two copies of pvalb-alpha, two copies of pvalb-beta 1, and five copies of pvalb-beta 2. This gene diversity is a result of teleost-specific whole-genome duplication. Two conserved parvalbumin genomic clusters carry pvalb-beta 1 and beta 2 copies, whereas pvalb-alpha genes are located separately in different linkage groups. Further, we investigated parvalbumin gene expression in 17 tissues of the common carp (Cyprinus carpio), a species with 21 parvalbumin genes in its genome. Two pvalb-alpha and eight pvalb-beta 2 copies are highly expressed in the muscle, while two alternative pvalb-alpha copies show expression in the brain and the testes, and pvalb-beta 1 is dominant in the retina and the kidney. The recent pairs of muscular pvalb-beta 2 genes show differential expression in this species. We provide robust genomic evidence of the complex evolution of the parvalbumin genes in fishes.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10603 - Genetics and heredity (medical genetics to be 3)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fishes

ISSN

2410-3888

e-ISSN

2410-3888

Volume of the periodical

6

Issue of the periodical within the volume

4

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

70

UT code for WoS article

000737137800001

EID of the result in the Scopus database

2-s2.0-85121284927