Oxygen transport kinetics underpin rapid and robustdiaphragm recovery following chronic spinal cord injury
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F21%3A00605514" target="_blank" >RIV/68378041:_____/21:00605514 - isvavai.cz</a>
Result on the web
<a href="https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280684" target="_blank" >https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP280684</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1113/JP280684" target="_blank" >10.1113/JP280684</a>
Alternative languages
Result language
angličtina
Original language name
Oxygen transport kinetics underpin rapid and robustdiaphragm recovery following chronic spinal cord injury
Original language description
Months after spinal cord injury (SCI), respiratory deficits remain the primary cause of morbidity and mortality for patients. It is possible to induce partial respiratory motor functional recovery in chronic SCI following 2 weeks of spinal neuroplasticity. However, the peripheral mechanisms underpinning this recovery are largely unknown, limiting development of new clinical treatments with potential for complete functional restoration. Utilizing a rat hemisection model, diaphragm function and paralysis was assessed and recovered at chronic time points following trauma through chondroitinase ABC induced neuroplasticity. We simulated the diaphragm's in vivo cyclical length change and activity patterns using the work loop technique at the same time as assessing global and local measures of the muscles histology to quantify changes in muscle phenotype, microvascular composition, and oxidative capacity following injury and recovery. These data were fed into a physiologically informed model of tissue oxygen transport. We demonstrate that hemidiaphragm paralysis causes muscle fibre hypertrophy, maintaining global oxygen supply, although it alters isolated muscle kinetics, limiting respiratory function. Treatment induced recovery of respiratory activity normalized these effects, increasing oxygen supply, restoring optimal diaphragm functional properties. However, metabolic demands of the diaphragm were significantly reduced following both injury and recovery, potentially limiting restoration of normal muscle performance. The mechanism of rapid respiratory muscle recovery following spinal trauma occurs through oxygen transport, metabolic demand and functional dynamics of striated muscle. Overall, these data support a systems-wide approach to the treatment of SCI, and identify new targets to mediate complete respiratory recovery.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physiology
ISSN
0022-3751
e-ISSN
1469-7793
Volume of the periodical
599
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
26
Pages from-to
1199-1224
UT code for WoS article
000591215200001
EID of the result in the Scopus database
2-s2.0-85096759178