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Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00563715" target="_blank" >RIV/68378041:_____/22:00563715 - isvavai.cz</a>

  • Alternative codes found

    RIV/86652036:_____/22:00563715 RIV/68378041:_____/22:00566908

  • Result on the web

    <a href="https://www.frontiersin.org/articles/10.3389/fncel.2022.1025012/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fncel.2022.1025012/full</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3389/fncel.2022.1025012" target="_blank" >10.3389/fncel.2022.1025012</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Recent advances in deciphering oligodendrocyte heterogeneity with single-cell transcriptomics

  • Original language description

    Oligodendrocytes (OL) have been for decades considered a passive, homogenous population of cells that provide support to neurons, and show a limited response to pathological stimuli. This view has been dramatically changed by the introduction of powerful transcriptomic methods that have uncovered a broad spectrum of OL populations that co-exist within the healthy central nervous system (CNS) and also across a variety of diseases. Specifically, single-cell and single-nucleus RNA-sequencing (scRNA-seq, snRNA-seq) have been used to reveal OL variations in maturation, myelination and immune status. The newly discovered immunomodulatory role suggests that OL may serve as targets for future therapies. In this review, we summarize the current understanding of OL heterogeneity in mammalian CNS as revealed by scRNA-seq and snRNA-seq. We provide a list of key studies that identify consensus marker genes defining the currently known OL populations. This resource can be used to standardize analysis of OL related datasets and improve their interpretation, ultimately leading to a better understanding of OL functions in health and disease.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2022

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Frontiers in Cellular Neuroscience

  • ISSN

    1662-5102

  • e-ISSN

    1662-5102

  • Volume of the periodical

    16

  • Issue of the periodical within the volume

    OCT 13 2022

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    8

  • Pages from-to

    1025012

  • UT code for WoS article

    000875842100001

  • EID of the result in the Scopus database

    2-s2.0-85140777633