Microglia-mediated degradation of perineuronal nets promotes pain
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F22%3A00566878" target="_blank" >RIV/68378041:_____/22:00566878 - isvavai.cz</a>
Result on the web
<a href="https://www.science.org/doi/10.1126/science.abl6773" target="_blank" >https://www.science.org/doi/10.1126/science.abl6773</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.abl6773" target="_blank" >10.1126/science.abl6773</a>
Alternative languages
Result language
angličtina
Original language name
Microglia-mediated degradation of perineuronal nets promotes pain
Original language description
Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets ( PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury-induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
1095-9203
Volume of the periodical
377
Issue of the periodical within the volume
6601
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
80-86
UT code for WoS article
000822009800046
EID of the result in the Scopus database
2-s2.0-85133903131