Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00579627" target="_blank" >RIV/68378041:_____/23:00579627 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/23:10469176 RIV/00216208:11110/23:10469176
Result on the web
<a href="https://www.nature.com/articles/s41416-023-02312-z" target="_blank" >https://www.nature.com/articles/s41416-023-02312-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41416-023-02312-z" target="_blank" >10.1038/s41416-023-02312-z</a>
Alternative languages
Result language
angličtina
Original language name
Probing the diabetes and colorectal cancer relationship using gene - environment interaction analyses
Original language description
BackgroundDiabetes is an established risk factor for colorectal cancer. However, the mechanisms underlying this relationship still require investigation and it is not known if the association is modified by genetic variants. To address these questions, we undertook a genome-wide gene-environment interaction analysis.MethodsWe used data from 3 genetic consortia (CCFR, CORECT, GECCO, 31,318 colorectal cancer cases/41,499 controls) and undertook genome-wide gene-environment interaction analyses with colorectal cancer risk, including interaction tests of genetics(G)xdiabetes (1-degree of freedom, d.f.) and joint testing of Gxdiabetes, G-colorectal cancer association (2-d.f. joint test) and G-diabetes correlation (3-d.f. joint test).ResultsBased on the joint tests, we found that the association of diabetes with colorectal cancer risk is modified by loci on chromosomes 8q24.11 (rs3802177, SLC30A8 - ORAA: 1.62, 95% CI: 1.34-1.96, ORAG: 1.41, 95% CI: 1.30-1.54, ORGG: 1.22, 95% CI: 1.13-1.31, p-value(3-d.f.): 5.46 x 10(-11)) and 13q14.13 (rs9526201, LRCH1 - ORGG: 2.11, 95% CI: 1.56-2.83, ORGA: 1.52, 95% CI: 1.38-1.68, ORAA: 1.13, 95% CI: 1.06-1.21, p-value(2-d.f.): 7.84 x 10(-09)).DiscussionThese results suggest that variation in genes related to insulin signaling (SLC30A8) and immune function (LRCH1) may modify the association of diabetes with colorectal cancer risk and provide novel insights into the biology underlying the diabetes and colorectal cancer relationship.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Cancer
ISSN
0007-0920
e-ISSN
1532-1827
Volume of the periodical
129
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
511-520
UT code for WoS article
001023567900001
EID of the result in the Scopus database
2-s2.0-85162876788