Genetic and non-genetic risk factors for early-onset pancreatic cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00581913" target="_blank" >RIV/68378041:_____/23:00581913 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/23:10458464 RIV/00216208:11120/23:43925300 RIV/00216208:11140/23:10458464 RIV/00064173:_____/23:43925300 and 2 more

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1590865823005145?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1590865823005145?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dld.2023.02.023" target="_blank" >10.1016/j.dld.2023.02.023</a>

Result language

angličtina

Original language name

Genetic and non-genetic risk factors for early-onset pancreatic cancer

Original language description

Background: Early-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC. Methods: A genome-wide association study was performed, analysing 912 EOPC cases and 10 222 controls, divided into discovery and replication phases. Furthermore, the associations between a polygenic risk score (PRS), smoking, alcohol consumption, type 2 diabetes and PDAC risk were also assessed. Results: Six novel SNPs were associated with EOPC risk in the discovery phase, but not in the replication phase. The PRS, smoking, and diabetes affected EOPC risk. The OR comparing current smokers to never smokers was 2.92 (95% CI 1.69-5.04, P = 1.44 x 10 -4). For diabetes, the corresponding OR was 14.95 (95% CI 3.41-65.50, P = 3.58 x 10 -4). Conclusion: In conclusion, we did not identify novel genetic variants associated specifically with EOPC, and we found that established PDAC risk variants do not have a strong age-dependent effect. Furthermore, we add to the evidence pointing to the role of smoking and diabetes in EOPC. (c) 2023 The Authors. Published by Elsevier Ltd on behalf of Editrice Gastroenterologica Italiana S.r.l. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30101 - Human genetics

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Digestive and Liver Disease

ISSN

1590-8658

e-ISSN

1878-3562

Volume of the periodical

55

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1417-1425

UT code for WoS article

001084748400001

EID of the result in the Scopus database

2-s2.0-85151481167