Increased macrophage M2/M1 ratio is associated with intracranial aneurysm rupture

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00583154" target="_blank" >RIV/68378041:_____/23:00583154 - isvavai.cz</a>

Alternative codes found

RIV/44555601:13450/22:43897299 RIV/00216208:11130/23:10450851 RIV/00216208:11110/23:10450851 RIV/00159816:_____/23:00079795 and 2 more

Result on the web

<a href="https://link.springer.com/article/10.1007/s00701-022-05418-0" target="_blank" >https://link.springer.com/article/10.1007/s00701-022-05418-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00701-022-05418-0" target="_blank" >10.1007/s00701-022-05418-0</a>

Result language

angličtina

Original language name

Increased macrophage M2/M1 ratio is associated with intracranial aneurysm rupture

Original language description

Purpose Intracranial aneurysm (IA) rupture results in one of the most severe forms of stroke, with severe neurological sequelae. Inflammation appears to drive aneurysm formation and progression with macrophages playing a key role in this process. However, less is known about their involvement in aneurysm rupture. This study is aimed at demonstrating how relationship between the M1 (pro-inflammatory) and M2 (reparative) macrophage subtypes affect an aneurysm's structure resulting in its rupture. Methods Forty-one saccular aneurysm wall samples were collected during surgery including 13 ruptured and 28 unruptured aneurysm sacs. Structural changes were evaluated using histological staining. Macrophages in the aneurysm wall were quantified and defined as M1 and M2 using HLA-DR and CD163 antibodies. Aneurysm samples were divided into four groups according to the structural changes and the M2/1 ratio. Data were analyzed using the Mann-Whitney U test. Results This study has demonstrated an association between the severity of structural changes of an aneurysm with inflammatory cell infiltration within its wall and subsequent aneurysm rupture. More severe morphological changes and a significantly higher number of inflammatory cells were observed in ruptured IAs (p < 0.001). There was a prevalence of M2 macrophage subtypes within the wall of ruptured aneurysms (p < 0.001). A subgroup of unruptured IAs with morphological and inflammatory changes similar to ruptured IAs was observed. The common feature of this subgroup was the presence of an intraluminal thrombus. Conclusions The degree of inflammatory cell infiltration associated with a shift in macrophage phenotype towards M2 macrophages could play an important role in structural changes of the aneurysm wall leading to its rupture.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Neurochirurgica

ISSN

0001-6268

e-ISSN

0942-0940

Volume of the periodical

165

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

177-186

UT code for WoS article

000889048800002

EID of the result in the Scopus database

2-s2.0-85142750069