Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00584709" target="_blank" >RIV/68378041:_____/23:00584709 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2090123223000061?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2090123223000061?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jare.2023.01.006" target="_blank" >10.1016/j.jare.2023.01.006</a>

Result language

angličtina

Original language name

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?

Original language description

Background: Synaptic dysfunction is a major contributor to Alzheimer ' s disease (AD) pathogenesis in addition to the formation of neuritic b-amyloid plaques and neurofibrillary tangles of hyperphosphorylated Tau protein. However, how these features contribute to synaptic dysfunction and axonal loss remains unclear. While years of considerable effort have been devoted to gaining an improved under -standing of this devastating disease, the unavailability of patient-derived tissues, considerable genetic heterogeneity, and lack of animal models that faithfully recapitulate human AD have hampered the development of effective treatment options. Ongoing progress in human induced pluripotent stem cell (hiPSC) technology has permitted the derivation of patient-and disease-specific stem cells with unlim-ited self-renewal capacity. These cells can differentiate into AD-affected cell types, which support studies of disease mechanisms, drug discovery, and the development of cell replacement therapies in traditional and advanced cell culture models.Aim of Review: To summarize current hiPSC-based AD models, highlighting the associated achievements and challenges with a primary focus on neuron and synapse loss.Key Scientific Concepts of Review: We aim to identify how hiPSC models can contribute to understanding AD-associated synaptic dysfunction and axonal loss. hiPSC-derived neural cells, astrocytes, and microglia, as well as more sophisticated cellular organoids, may represent reliable models to investigate AD and identify early markers of AD-associated neural degeneration.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/EF15_003%2F0000419" target="_blank" >EF15_003/0000419: Center of Reconstructive Neuroscience</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Advanced Research

ISSN

2090-1232

e-ISSN

2090-1224

Volume of the periodical

54

Issue of the periodical within the volume

dec.

Country of publishing house

EG - EGYPT

Number of pages

14

Pages from-to

105-118

UT code for WoS article

001127856800001

EID of the result in the Scopus database

2-s2.0-85147128554