Bio-inspired nanoporous scaffold: electrospun hybrid fibers based on self-assembled block copolymer mineralized with inorganic nanoparticles for bone tissue engineering
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00581666" target="_blank" >RIV/68378041:_____/24:00581666 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/00914037.2023.2243369" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/00914037.2023.2243369</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/00914037.2023.2243369" target="_blank" >10.1080/00914037.2023.2243369</a>
Alternative languages
Result language
angličtina
Original language name
Bio-inspired nanoporous scaffold: electrospun hybrid fibers based on self-assembled block copolymer mineralized with inorganic nanoparticles for bone tissue engineering
Original language description
Mineralized, bio-inspired nanofibrous scaffolds with controllable architecture and capable of mimicking essential characteristics of bone extracellular matrix at the micro- and nanoscale offer a promising strategy to restore functions or elicit favorable responses for bone tissue regeneration and repair. In this study, a simple approach to fabricate a hybrid scaffold with porous fibers for bone tissue engineering is presented. Non-woven multifunctional nano- and microfibers were fabricated using a block copolymer of poly(e-caprolactone) (PCL) and poly(lactic acid) (PLA) (PL-b-CL) as a matrix and hydroxyapatite (HA) as a functional agent, dissolved in a binary solvent mixture. Physicochemical and thermal characterization as well as biocompatibility analyses were carried out using SaOS-2 cells. The results showed fibers with highly porous surfaces whose pore diameters range in the nanometer scale and all scaffolds exhibited hydrophobicity. HA-modified scaffolds significantly improved cell metabolic activity and proliferation as compared to pristine scaffolds. The biodegradable and biocompatible scaffolds proposed in this study carry great potential for various biomedical applications and in the future, it is expected that they can be used for controlled drug delivery by incorporating growth factors, proteins, or drugs to reduce the inflammatory response and/or to promote bone repair.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Polymeric Materials and Polymeric Biomaterials
ISSN
0091-4037
e-ISSN
1563-535X
Volume of the periodical
73
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
1054-1067
UT code for WoS article
001061395400001
EID of the result in the Scopus database
2-s2.0-85169807589