Rupture point is associated with divergent hemodynamics in intracranial aneurysms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00600900" target="_blank" >RIV/68378041:_____/24:00600900 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/24:00600900 RIV/44555601:13450/24:43898546 RIV/00216208:11320/24:10483716 RIV/00159816:_____/24:00081562 RIV/00216224:14110/24:00139941
Result on the web
<a href="https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1364105/full" target="_blank" >https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1364105/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fneur.2024.1364105" target="_blank" >10.3389/fneur.2024.1364105</a>
Alternative languages
Result language
angličtina
Original language name
Rupture point is associated with divergent hemodynamics in intracranial aneurysms
Original language description
Background: Understanding the risk factors leading to intracranial aneurysm (IA) rupture have still not been fully clarified. They are vital for proper medical guidance of patients harboring unruptured IAs. Clarifying the hemodynamics associated with the point of rupture could help could provide useful information about some of the risk factors. Thus far, few studies have studied this issue with often diverging conclusions.nMethods: We identified a point of rupture in patients operated for an IAs during surgery, using a combination of preoperative computed tomography (CT) and computed tomography angiography (CTA). Hemodynamic parameters were calculated both for the aneurysm sac as a whole and the point of rupture. In two cases, the results of CFD were compared with those of the experiment using particle image velocimetry (PIV).nResults: We were able to identify 6 aneurysms with a well-demarcated point of rupture. In four aneurysms, the rupture point was near the vortex with low wall shear stress (WSS) and high oscillatory shear index (OSI). In one case, the rupture point was in the flow jet with high WSS. In the last case, the rupture point was in the significant bleb and no specific hemodynamic parameters were found. The CFD results were verified in the PIV part of the study.nConclusion: Our study shows that different hemodynamic scenarios are associated with the site of IA rupture. The numerical simulations were confirmed by laboratory models. This study further supports the hypothesis that various pathological pathways may lead to aneurysm wall damage resulting in its rupture.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/NU22-08-00124" target="_blank" >NU22-08-00124: Blood flow modelling in intracranial vessels in relationship to endothelium changes and development of intracranial aneurysms</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Neurology
ISSN
1664-2295
e-ISSN
1664-2295
Volume of the periodical
15
Issue of the periodical within the volume
May
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
1364105
UT code for WoS article
001237269700001
EID of the result in the Scopus database
2-s2.0-85195107251