Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F24%3A00603829" target="_blank" >RIV/68378041:_____/24:00603829 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10481671 RIV/00216208:11120/24:43927295 RIV/00216208:11140/24:10481671 RIV/00064173:_____/24:43927295 RIV/00098892:_____/24:10158736
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/ijc.35046" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ijc.35046</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.35046" target="_blank" >10.1002/ijc.35046</a>

Result language
angličtina
Original language name
Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk
Original language description
Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs in 14,394 cases and 247,022 controls of European and Asian descent. We observed that the A allele of the rs2976395 SNP was associated with increased PDAC risk in Europeans (p = 2.81 × 10−5). This SNP lies in the prostate stem cell antigen gene and is in perfect linkage disequilibrium with a variant (rs2294008) that has been reported to be associated with risk of many other cancer types. The A allele is associated with the DNA methylation level of the gene according to the PanCan-meQTL database and with overexpression according to QTLbase. The expression of the gene has been observed to be deregulated in many tumors of the gastrointestinal tract including pancreatic cancer, however, functional studies are needed to elucidate the function relevance of the association.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
<a href="/en/project/NU21-03-00499" target="_blank" >NU21-03-00499: Prospective study on early pancreatic cancer detection and therapy monitoring using lipidomic profiling by mass spectrometry</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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