Hybrid fibres: a new path in tissue regeneration
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00618586" target="_blank" >RIV/68378041:_____/25:00618586 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/25:00618586 RIV/46747885:24410/25:00013449 RIV/46747885:24510/25:00013449 RIV/46747885:24620/25:00013449
Result on the web
<a href="https://doi.org/10.1007/s10856-025-06875-6" target="_blank" >https://doi.org/10.1007/s10856-025-06875-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10856-025-06875-6" target="_blank" >10.1007/s10856-025-06875-6</a>
Alternative languages
Result language
angličtina
Original language name
Hybrid fibres: a new path in tissue regeneration
Original language description
Nowadays, various forms of organosilane materials are well established in the field of regenerative medicine, but interestingly, fibrous organosilanes have yet to be described. So far, technological obstacles prevent the preparation of such fibrous materials without any presence of spinnability-supporting organic polymers, various types of surfactants, or non-polar organic solvents, which are in many cases highly toxic and economically inconvenient. Recently, these obstacles were overcome by a complex, yet simple, technology combining different science perspectives from supramolecular chemistry through material science to tissue engineering. This paper suggests a synthesis of two biomedically promising monomeric organosilane precursors, N,N<acute accent>-bis(3-(triethoxysilyl)propyl)terephthalamide (BTT) and N,N<acute accent>-bis(3-(triethoxysilyl)propyl)pyridine-2,6-dicarboxamide (BTP), which are submitted to a sol-gel process combined with subsequent electrospinning technology. Such a unique procedure not only allows the preparation of toxic-free organosilane fibrous mats by suitable adjustment of sol-gel and electrospinning parameters but also simplifies material production via a one-pot synthesis approach further tuneable with appropriate organosilane precursors. The BTT and BTP fibrous materials prepared displayed not only a promising interface among the materials and 3T3 fibroblast cell lines but moreover, the interaction of nanofibrous materials with stem cells has yielded encouraging outcomes. Stem cell adhesion, proliferation, and differentiation were notably enhanced in the presence of these materials, suggesting a supportive microenvironment conducive to regenerative responses. The ability of the material to modulate the cellular behaviour of stem cells holds promising implications for the development of targeted and effective regenerative therapies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30404 - Biomaterials (as related to medical implants, devices, sensors)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Materials Science-Materials in Medicine
ISSN
0957-4530
e-ISSN
1573-4838
Volume of the periodical
36
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
29
Pages from-to
29
UT code for WoS article
001454333500002
EID of the result in the Scopus database
2-s2.0-105001326299