Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F25%3A00636275" target="_blank" >RIV/68378041:_____/25:00636275 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10497867 RIV/00216208:11140/25:10497867 RIV/00216208:11310/25:10497867 RIV/00098892:_____/25:10159263
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1044579X25000628?via%3Dihub#ack0005" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1044579X25000628?via%3Dihub#ack0005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.semcancer.2025.05.005" target="_blank" >10.1016/j.semcancer.2025.05.005</a>

Result language
angličtina
Original language name
Genomic instability, DNA damage response and telomere homeostasis in pancreatic cancer
Original language description
Pancreatic cancer (PC) is becoming one of the most serious health problems at present, but its causes and risk factors are still unclear. One of the drivers in pancreatic carcinogenesis is altered genomic (DNA) integrity with subsequent genomic instability in cancer cells. The latter comprises a) DNA damage response and DNA repair mechanisms, b) DNA replication and mitosis, c) epigenetic regulation, and d) telomere maintenance. In our review we addressed the above aspects in relation to the most abundant and severe form of PC, pancreatic ductal adenocarcinoma (PDAC). In summary, the interactions between the DNA damage response, telomere homeostasis and mitotic regulation are not comprehensively understood at present, including the epigenetic factors entering the trait of genomic stability maintenance. In addition, the complexity of telomere homeostasis in relation to PDAC risk, prognosis and prediction also warrants further investigations.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
<a href="/en/project/NU21-07-00247" target="_blank" >NU21-07-00247: Concept of liquid biopsy in mapping of microRNA and oncogenic KRAS mutations for early diagnosis and risk assessment of pancreatic cancer.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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