An ex vivo model to study v-Myb-induced leukemogenicity.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F01%3A23010249" target="_blank" >RIV/68378050:_____/01:23010249 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/01:23000249

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

An ex vivo model to study v-Myb-induced leukemogenicity.

Original language description

The v-Myb oncoprotein transforms myeloid cells and induces acute monoblastic leukemia in chickens. We found that deletion of v-Myb PEST-like (P1) domain almost eliminates presence of leukemic monoblasts in the peripheral blood but not their accumulationin the bone marrow (BM). Ex vivo experiments used to compare wild type (wt) and .delta.P1 v-Myb BM monoblasts led to the conclusion that leukemia formation requires the growth factor independency and specific adhesion properties induced in monoblasts bywt v-Myb.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood Cells, Molecules, and Diseases

ISSN

1079-9796

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

2

Country of publishing house

CA - CANADA

Number of pages

9

Pages from-to

437-445

UT code for WoS article

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EID of the result in the Scopus database

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