Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F01%3A23010305" target="_blank" >RIV/68378050:_____/01:23010305 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Release from tonic inhibition of T cell activation through transient displacement of C-terminal Src kinase (Csk) from lipid rafts.

Original language description

Upon triggering of the TCR, PAG is dephosphorylated resulting in loss of Csk from lipid rafts. Tyr-phosphorylation of PAG resumes after 3-5 min, and Csk reassociates with rafts. Cells expressing a mutant Csk without catalytic domain have elevated levelsof TCR-zeta phosphorylation and spontaneous activation of an NFAT-AP1 reporter and stronger responses to TCR triggering. Transient release from Csk-mediated inhibition by displacement of Csk from lipid rafts may be important for normal T cell activation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/IAA7052904" target="_blank" >IAA7052904: Signalling molecules of immunocytes: regulation of their activity by redox mechanisms and membrane compartmentalization</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Biological Chemistry

ISSN

0021-9258

e-ISSN

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Volume of the periodical

276

Issue of the periodical within the volume

31

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

29313-29318

UT code for WoS article

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EID of the result in the Scopus database

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