A DNA polymerase epsilon inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F01%3A23010335" target="_blank" >RIV/68378050:_____/01:23010335 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A DNA polymerase epsilon inhibitor activates the ribo and deoxyribo modes of primase expression and induces a unique phenomenon of primer accumulation.

Original language description

Using direct analysis of the reaction products with radioactively labelled RNA or DNA, the ribo and deoxyribo mode of expression of Pr activities of the Pr-alpha DNA pol enzyme complex was compared in the presence of COMDP, as well as the influence of the presence of MIMO and BuPdGTP on the effect of COMDP. From the new findings obtained the concept was formulated of the bimodal effect of COMDP on the active site responsible for the ribo and deoxyribo mode of Pr expression and on the active site responsible for the coupling of Pr and alpha DNA pol activities into one reaction of the Pr-alpha DNA pol enzyme complex.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

FEBS Letters

ISSN

0014-5793

e-ISSN

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Volume of the periodical

505

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

141-146

UT code for WoS article

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EID of the result in the Scopus database

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