Adaptation of a CXCR4-using human immunodeficiency type 1 NDK virus in intestinal cells is associated with CD4-independent replication.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F02%3A23023091" target="_blank" >RIV/68378050:_____/02:23023091 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/02:23033190
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Adaptation of a CXCR4-using human immunodeficiency type 1 NDK virus in intestinal cells is associated with CD4-independent replication.
Original language description
We demonstrate that the envelope gene of intestinal cell-adapted virus conferred to recombinant clone HIV-1 iNDK the ability to ulitize CXCR4 without CD4 while retaining its rtopism for CD4 lymphocytes. The study suggest that CD4-independent use of CXCR4can be mediated by different adaptive changes related to the microenvironment of CD4- cell.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Virology
ISSN
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e-ISSN
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Volume of the periodical
304
Issue of the periodical within the volume
N/A
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
403-414
UT code for WoS article
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EID of the result in the Scopus database
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