Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F02%3A23033137" target="_blank" >RIV/68378050:_____/02:23033137 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Apoptosis induction by iron deprivation in tumor cells: role of mitochondria and caspases.
Original language description
Iron deprivation specifically induces apoptosis in some tumor cells while other tumor cells are resistant. We have shown previously that the p53 pathway, including p53 activation and subsequent regulation of the expression of relevant genes of the bcl-2family such as bax and bcl-2, is not involved in apoptosis induction by iron deprivation. In the present study we compared the activity of caspase-3 and caspase-9 in sensitive (38C13) versus resistant (EL4) cells under control and iron-depriving conditions. Iron deprivation resulted in a significant increase of the caspase-3 activity in sensitive but not in resistant cells. Similarly, we detected caspase-9 activation under iron deprivation in sensitive but not in resistant cells. We also compared the distribution of some proteins of the Bcl-2 family in sensitive versus resistant cells under control and iron-depriving conditions. Confocal microscopy revealed that iron deprivation resulted in Bax protein translocation from the cytosol to
Czech name
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Czech description
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Publication year
2002
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Abstracts of the 25th Meeting of the European Study Group for Cell Proliferation (ESGCP).
ISBN
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ISSN
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e-ISSN
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Number of pages
2
Pages from-to
2
Publisher name
Blackwell Publishing
Place of publication
UK
Event location
Reims [FR]
Event date
Oct 24, 2002
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
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