A unification of mosaic structures in the human genome.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F03%3A23033183" target="_blank" >RIV/68378050:_____/03:23033183 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A unification of mosaic structures in the human genome.
Original language description
The human genome is a mosaic structure on many levels: there exist cytogenetic bands, GC composition bands (isochores) and clusters of broadly expressed genes. How might these inter-relate? It has been proposed that to optimize gene regulation, housekeeping genes should concentrate on transcriptionally competent chromosomal domains. Prior evidence suggests that regions of high GC and R bands are associated with such domains. Here we report that broadly expressed genes cluster in regions of high GC, andin R and lightest Giemsa bands. This is not only a confirmation of the adaptive hypothesis, but is also the first direct systematic evidence of a general interdependence of expression patterns with base composition and chromosome structure.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2003
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Human molecular genetics
ISSN
0964-6906
e-ISSN
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Volume of the periodical
2003
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
2411-2415
UT code for WoS article
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EID of the result in the Scopus database
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