The Optimedin gene is a downstream target of Pax6
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F05%3A00027790" target="_blank" >RIV/68378050:_____/05:00027790 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The Optimedin gene is a downstream target of Pax6
Original language description
The Optimedin gene, also known as Olfactomedin 3, encodes an olfactomedin domain-containing protein. There are two major splice variants of the Optimedin mRNA, Optimedin A and Optimedin B, transcribed from different promoters. The expression pattern of the Optimedin A variant in the eye and brain overlaps with that for Pax6, which encodes a protein containing the paired and homeobox DNA-binding domains. The Pax6 gene plays a critical role for the development of eyes, central nervous system, and endocrine glands. The proximal promoter of the Optimedin A variant contains a putative Pax6 binding site in position ?86/?70. Pax6 binds this site through the paired domain in vitro as judged by electrophoretic mobility shift assay. Mutations in this site eliminate Pax6 binding as well as stimulation of the Optimedin promoter activity by Pax6 in transfection experiments. Altogether these results identify the Optimedin gene as a downstream target regulated by Pax6.
Czech name
Gen pro optimedin je cílovým genem Pax6
Czech description
Gen pro Optimedin (olfactomedin 3) ma dvě formy mRNA, Optimedin A a Optimedin B, které se tvoří s použitím různých promotorů. Expresní profil Optimedin A odpovídá expresnímu profilu genu Pax6, který koduje transkripční faktor. Promotor Optimedin A obsahuje vazebné sekvence Pax6. Mutace těchto míst eliminuje vazbu Pax6 a stimulaci promotoru. Tyto výsledky ukazují, že gen pro Optimedin je cílovým genem Pax6.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA204%2F04%2F1358" target="_blank" >GA204/04/1358: The role of wnt signalling in eye development and lens cell differentiation</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Biological Chemistry
ISSN
0021-9258
e-ISSN
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Volume of the periodical
280
Issue of the periodical within the volume
42
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
35228-35237
UT code for WoS article
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EID of the result in the Scopus database
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