Blockade of AT1 receptors by losartan did not affect renin gene expression in kidney medulla

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F06%3A00047062" target="_blank" >RIV/68378050:_____/06:00047062 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Blockade of AT1 receptors by losartan did not affect renin gene expression in kidney medulla

Original language description

This study was designed to determine particular changes in the renin gene expression and activity in renal cortex and medulla after AT(1) receptor blockade. It was found that two-week treatment with AT(1) blocker losartan induced an increase in tissue renin activity in both parts of kidney causing subsequent elevation of plasma renin activity. Renin mRNA in losartan-treated rats was increased only in the cortex, suggesting cortex origin of elevated renin activity in medulla. Medullary renin mRNA indicated local synthesis of renin within the whole kidney and supported the idea of the presence of tissue renin-angiotensin system. Our results show that gene expression of renin in kidney medulla is insensitive to AT(1) receptor blockade and this points outthat the regulation of kidney renin-angiotensin system probably differs from that in the cortex.

Czech name

Blokování AT1 receptorů losartanem neovlivnilo expresi genu pro renin v dřeni ledvin

Czech description

Studie sledovala hlavní změny v expresi reninového genu a reninové aktivity v kůře a dřeni ledvin po 2 týdenním blokování AT(1) receptoru losartanem. Aktivita reninu v obou částech ledvin a tím i aktivita reninu v plasmě se zvýšila. Produkce mRNA pro renin se zvýšila jen v kůře ledvin, zatímco v dřeni nereagovala na blokádu AT (1) receptorů. To naznačuje, že regulace renin-angiotensinového systému v ledvinách je odlišná v kůře a v dřeni.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

General Physiology and Biophysics

ISSN

0231-5882

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

1

Country of publishing house

SK - SLOVAKIA

Number of pages

9

Pages from-to

43-51

UT code for WoS article

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EID of the result in the Scopus database

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