Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F07%3A00094603" target="_blank" >RIV/68378050:_____/07:00094603 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo

Original language description

Drosophila retinal determination gene network in animals is generally Pax-Six-Eyes absent-Dachshund (PSEDN). We describe complete amphioxus network of 9 PSEDN genes, 4 of which are characterized here for the first time. In vitro interactions among the genes and proteins of amphioxus network resemble those of other animals except for Dach-Eya binding absence. Amphioxus PSEDN genes are expressed in highly stage- and tissue-specific patterns in the gastrular organizer, notochord, somites, anterior centralnervous system, peripheral nervous system, pharyngeal endoderm and the likely homolog of vertebrate adenohypophysis, whose anterior region expresses all amphioxus Six genes and is cell proliferation-active, while the posterior one expresses only AmphiPax6 and is non-proliferative. Topologies of animal PSEDNs, though much more variable than supposed, arethus conserved among species and developing tissues; PSEDNs thus play a key role in critically important early phases of embryology.

Czech name

Síť Pax-Six-Eya-Dach ve vývoji kopinatce: konzervace in vitro ale kontextová specifita in vivo

Czech description

Popisujeme pax-six-eyes absent-dachshund síť (psedn) u kopinatce. Všeobecně se interakce mezi geny a proteiny ze sítě podobají těm z jiných zvířat, s výjimkou absencí dach-eya vazby. Geny psedn se projevují ve vysoce specifických vzorcích zejména v gastrule, notochordu, somitech, centrální nervové soustavy, okrajové nervové soustavy, pharyngealním entodermu. Konzervace psedn může odrážet nepostradatelnou angažovanost genů psedns během kriticky důležité rané fáze embryonálního vývoje.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/IAA500520604" target="_blank" >IAA500520604: Developmental Genetics of Amphioxus:Insight into Evolutionary Origin of Vertebrates</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Developmental Biology

ISSN

0012-1606

e-ISSN

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Volume of the periodical

306

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

17

Pages from-to

143-159

UT code for WoS article

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EID of the result in the Scopus database

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