Therapy for minimal residual tumour disease: beta-galactosylceramide inhibits growth of recurrent HPV16-associated neoplasms after surgery and chemotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F10%3A00333598" target="_blank" >RIV/68378050:_____/10:00333598 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Therapy for minimal residual tumour disease: beta-galactosylceramide inhibits growth of recurrent HPV16-associated neoplasms after surgery and chemotherapy

Original language description

This study was focused on tumour-inhibitory effects of 12 carbon acyl chain beta-galactosylceramide (C12 beta-D-GalactosylCeramide) on the growth of HPV16-associated neoplasms transplanted in syngeneic mice. Treatment of tumour-bearing mice with beta-galactosylceramide 3-14 days after tumour cell transplantation significantly inhibited growth of the MHC class I-positive (TC-1), as well as MHC class I-deficient (TC-1/A9) HPV16-asssociated tumours. Administration of beta-galactosylceramide after surgicalremoval of TC-1 tumours inhibited growth of tumour recurrences. Similar results were obtained in the treatment of the tumours after chemotherapy. Beta-galactosylceramide treatment turned out to be also synergistic with immunotherapy based on administration of IL-12-producing cellular vaccines. These results suggest that beta-galactosylceramide can be effective for treatment of minimal residual tumour disease as well as an adjuvant for cancer immunotherapy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cancer

ISSN

0020-7136

e-ISSN

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Volume of the periodical

126

Issue of the periodical within the volume

12

Country of publishing house

DE - GERMANY

Number of pages

2

Pages from-to

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UT code for WoS article

000277551100025

EID of the result in the Scopus database

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