Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00357770" target="_blank" >RIV/68378050:_____/11:00357770 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/11:00357770 RIV/00216224:14310/11:00062480 RIV/68081707:_____/11:00391594
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway
Original language description
Platinum complexes LA-12 and cisplatin enhanced TRAIL-induced apoptosis in colon and prostate cancer cells. They increased surface expression of DR5 receptor for TRAIL, which has been shown to be crucial for induction of apoptosis. Moreover, LA-12 and cisplatin mediated translocation of TRAIL receptors DR4 and DR5 to lipid rafts and enhanced internalization of TRAIL. These events modulated early steps of TRAIL, signaling and may contribute to induction of apoptosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Carcinogenesis
ISSN
0143-3334
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
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UT code for WoS article
000286303000007
EID of the result in the Scopus database
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