Genetically modified tumour vaccines producing IL-12 augment chemotherapy of HPV16-associated tumours with gemcitabine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00365072" target="_blank" >RIV/68378050:_____/11:00365072 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3892/or.2011.1221" target="_blank" >http://dx.doi.org/10.3892/or.2011.1221</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2011.1221" target="_blank" >10.3892/or.2011.1221</a>

Result language

angličtina

Original language name

Genetically modified tumour vaccines producing IL-12 augment chemotherapy of HPV16-associated tumours with gemcitabine

Original language description

Genetically modified tumour cells producing cytokines such as IL-12 are potent activators of antitumour immune responses and a promising therapeutic modality when combined with chemotherapy. We examined whether IL-12-producing cellular vaccines can augment chemotherapy of HPV 16-associated murine tumours with cytostatic agent gemcitabine (GEM). Peritumoral administration of IL-12-producing tumour vaccines enhanced the effect of cytoreductive therapy with GEM in non-metastasizing murine carcinoma TC-1 and in metastasizing murine carcinoma MK16. Lung metastases in mice were substantially decreased. In surgical minimal residual tumour disease IL-12-producing tumour vaccine and GEM after MK16 tumour surgery also reduced tumour recurrences and metastases. Tumour inhibitory effects of GEM plus IL-12 were associated with high production of interferon-? by splenocytes. IL-12-producing vaccine can thus enhance the effect of GEM chemotherapy in some HPV16-associated murine tumour models.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

6

Country of publishing house

GR - GREECE

Number of pages

7

Pages from-to

1683-1689

UT code for WoS article

000290649600027

EID of the result in the Scopus database

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