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Genetically modified tumour vaccines producing IL-12 augment chemotherapy of HPV16-associated tumours with gemcitabine

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00365072" target="_blank" >RIV/68378050:_____/11:00365072 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.3892/or.2011.1221" target="_blank" >http://dx.doi.org/10.3892/or.2011.1221</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3892/or.2011.1221" target="_blank" >10.3892/or.2011.1221</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Genetically modified tumour vaccines producing IL-12 augment chemotherapy of HPV16-associated tumours with gemcitabine

  • Original language description

    Genetically modified tumour cells producing cytokines such as IL-12 are potent activators of antitumour immune responses and a promising therapeutic modality when combined with chemotherapy. We examined whether IL-12-producing cellular vaccines can augment chemotherapy of HPV 16-associated murine tumours with cytostatic agent gemcitabine (GEM). Peritumoral administration of IL-12-producing tumour vaccines enhanced the effect of cytoreductive therapy with GEM in non-metastasizing murine carcinoma TC-1 and in metastasizing murine carcinoma MK16. Lung metastases in mice were substantially decreased. In surgical minimal residual tumour disease IL-12-producing tumour vaccine and GEM after MK16 tumour surgery also reduced tumour recurrences and metastases. Tumour inhibitory effects of GEM plus IL-12 were associated with high production of interferon-? by splenocytes. IL-12-producing vaccine can thus enhance the effect of GEM chemotherapy in some HPV16-associated murine tumour models.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oncology Reports

  • ISSN

    1021-335X

  • e-ISSN

  • Volume of the periodical

    25

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GR - GREECE

  • Number of pages

    7

  • Pages from-to

    1683-1689

  • UT code for WoS article

    000290649600027

  • EID of the result in the Scopus database