Where splicing joins chromatin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00371260" target="_blank" >RIV/68378050:_____/11:00371260 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4161/nucl.2.3.15876" target="_blank" >http://dx.doi.org/10.4161/nucl.2.3.15876</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4161/nucl.2.3.15876" target="_blank" >10.4161/nucl.2.3.15876</a>

Result language
angličtina
Original language name
Where splicing joins chromatin
Original language description
There are numerous data suggesting that two key steps in gene expression - transcription and splicing influence each other closely. For a long time it was known that chromatin modifications regulate transcription, but only recently it was shown that chromatin and histone modifications play a significant role in pre-mRNA splicing. Here we summarize interactions between splicing machinery and chromatin and discuss their potential functional significance. We focus mainly on histone acetylation and methylation and potential mechanisms of their role in splicing. It seems that whereas histone acetylation acts mainly by alterating the transcription rate, histone methylation can also influence splicing directly by recruiting various splicing components.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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