Cytoskeleton in mast cell signaling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00378914" target="_blank" >RIV/68378050:_____/12:00378914 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3389/fimmu.2012.00130" target="_blank" >http://dx.doi.org/10.3389/fimmu.2012.00130</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2012.00130" target="_blank" >10.3389/fimmu.2012.00130</a>
Alternative languages
Result language
angličtina
Original language name
Cytoskeleton in mast cell signaling
Original language description
This review article presents a critical survey of current knowledge on the role of cytokeleton in mast cell signaling. Mast cell activation mediated by the high affinity receptor for IgE (Fc?RI) is a key event in allergic response and inflammation. Activation of various signaling pathways results in changes in cell morphology, adhesion to substrate, exocytosis, and migration. Reorganization of cytoskeleton is pivotal in all these processes. Highly dynamic microtubules formed by ??-tubulin dimers as wellas microfilaments build up from polymerized actin are affected in activated cells by kinases/phosphatases, Rho GTPases and changes in concentration of cytosolic Ca2+. The dynamic nature of microtubules and microfilaments in activated cells also dependson many associated/regulatory proteins. In this review, we have summarized recent developments in the biology of cytoskeleton and the role of signaling pathways in the course of mast cell activation.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
—
Volume of the periodical
3
Issue of the periodical within the volume
May
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
—
UT code for WoS article
—
EID of the result in the Scopus database
—